Chat with us, powered by LiveChat Describe the contribution of Blactamases to the indirect pathogenicity of some bacteria - Aqhomework

Describe the contribution of Blactamases to the indirect pathogenicity of some bacteria

Antimicrobial Chemotherapies Assignment 2, 2014 Please be sure to appropriately reference the sources used Enzymes are significant in the mode of action of antibiotics (as targets) and in the resistance of bacteria to the action of antibiotics (as inactivating agents). In resistant cells there may be differences in enzymes compared with sensitive cells or the expression of enzymes may be different, These differences may be due to chromosomal changes (mutations; transposons) or to genes on plasmids. Q1. (a) Use the mechanisms of resistance to beta-lactams discussed in GG p.1479 (12? Ed ? online text via the library) to explain i) The beta-Iactam resistance shown by S. aureus M908 ii) The beta-Iactam resistance shown by S. aureus CP11 [2 marks] (b)How is the resistance shown by newly-emerging resistant gram-negative organisms carrying the NDM-1 gene different to those discussed in 1 (a)? [1 mark] (c) Examine the data collected for the aminoglycoside activities against strains CP10 and CP11. DISCUSS the possible mechanism for the SmR in these strains from the options set out in Goodman and Gilman. (Be concise and make it clear how you use the data in reaching your conclusion. You are asked for one choice and the reason for that choice instead of the others). [2 marks] 02. Describe the contribution of B-lactamases to the indirect pathogenicity of some bacteria. [2 marks] See Maddocks,JL. Indirect pathogenicity. Journal of Antimicrobial Chemotherapy 1980; 6: 307-309. Also an Addendum at page 807 in this volume. and Brook /. The concept of indirect pathogenicity by B-Iactamase production, especially in ear, nose and throat infection. Journal of Antimicrobial Chemotherapy 1989; 24 Suppl. B: 63-72. [These are the significant early papers on this concept. A more recent review is available online from the library. Clin. Microbiol. Infect. 2004 Sep; 10(9): 777-84.] AC220 Assignment 2 2013 Q3. (a)For most infections, monotherapy is preferred to combination therapy but in some circumstances, combination therapy is warranted. Care must be taken when combining antimicrobials because although there are advantages-there may also be disadvantages. Use the results of the checkerboard titration of Ne/sserla gonorrhoea and Proteus mirabilis obtained during session 11 to prepare a clearly labelled isobologram. [0.5marks] (b)Refer to GG p1103 to explain your isobologram results. [1.5 marks] Q4. A consideration of the concept of antibiotic stewardship was first introduced into the Antibiotic Guidelines in version 14 (p.7). Describe how the role of an ?antibiotic pharmacist? contributes to antibiotic stewardship. [1 mark] [Q4 will not be in textbooks and will need to be searched on-line. Use at least two references]

Our website has a team of professional writers who can help you write any of your homework. They will write your papers from scratch. We also have a team of editors just to make sure all papers are of HIGH QUALITY & PLAGIARISM FREE. To make an Order you only need to click Ask A Question and we will direct you to our Order Page at WriteDemy. Then fill Our Order Form with all your assignment instructions. Select your deadline and pay for your paper. You will get it few hours before your set deadline.

Fill in all the assignment paper details that are required in the order form with the standard information being the page count, deadline, academic level and type of paper. It is advisable to have this information at hand so that you can quickly fill in the necessary information needed in the form for the essay writer to be immediately assigned to your writing project. Make payment for the custom essay order to enable us to assign a suitable writer to your order. Payments are made through Paypal on a secured billing page. Finally, sit back and relax.

Do you need an answer to this or any other questions?

Do you need help with this question?

Get assignment help from Paper Writing Website and forget about your problems.

Aqhomework provides custom & cheap essay writing 100% original, plagiarism free essays, assignments & dissertations.

With an exceptional team of professional academic experts in a wide range of subjects, we can guarantee you an unrivaled quality of custom-written papers.

Click Order now to access our order form, fill your paper details correctly, select your paper deadline and wait for our writers to send a perfectly written assignment. 

Chat with us today! We are always waiting to answer all your questions.