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Explain the pathogenesis causing the clinical mani

Explain the pathogenesis causing the clinical manifestations with which Mrs Brown presented.Mrs Brown, a 78 year-old female, was admitted to the Emergency Department at 6am after waking up with severe breathlessness. Her family informed you that the patient has a history of heart failure that had been diagnosed two years ago. On admission to the Emergency Department the clinical manifestations were:Severe dyspnoeaRespiratory rate of 24 breaths/minuteSpO2 85%, on room airBP 170/95mmHgPulse rate of 120 beats/minuteAuscultation of lungs identifies bilateral basal cracklesMrs Brown was connected to an ECG monitor that showed atrial fibrillation. A diagnosis of acute exacerbation of chronic left-sided heart failure was made.Question 1. (500 words) (Learning outcome 1 and 5)Explain the pathogenesis causing the clinical manifestations with which Mrs Brown presented.Question 2. (200 words) (Learning outcomes 2, 4 and 5)Discuss two high priority nursing strategies to manage Mrs Brown and provide evidence-based rationales for these strategies.Question 3. (300 words) (Learning outcome 3 and 5)Two of the drugs that were given to Mrs Brown were IV furosemide and sublingual glyceryl trinitrate.Discuss the mechanism of action of these two drugs, and relate to the underlying pathogenesis of an acute exacerbation of chronic left-sided heart failure. And,Describe the nursing implications (monitoring for and responding to adverse effects, and evaluating therapeutic effect) when administering these two drugs to a patient with an acute exacerbation of chronic left-sided heart failure.

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